NH4Cl Catalyzed synthesis of β-amino Esters
نویسندگان
چکیده
منابع مشابه
Isothiourea-catalyzed asymmetric synthesis of β-lactams and β-amino esters from arylacetic acid derivatives and N-sulfonylaldimines.
The isothiourea HBTM-2.1 (5 mol %) catalyzes the asymmetric formal [2 + 2] cycloaddition of both arylacetic acids (following activation with tosyl chloride) and preformed 2-arylacetic anhydrides with N-sulfonylaldimines, generating stereodefined 2,3-diaryl-β-amino esters (after ring-opening) and 3,4-diaryl-anti-β-lactams, respectively, with high diastereocontrol (up to >95:5 dr) and good to exc...
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ژورنال
عنوان ژورنال: Results in Chemistry
سال: 2020
ISSN: 2211-7156
DOI: 10.1016/j.rechem.2020.100036